| First Lady |
Abigail Fillmore |
| Vice President |
none |
| Secretary of State |
Edward Everett (1852–1853) |
| Secretary of State |
Daniel Webster (1850–1852) |
| Secretary of State |
John M. Clayton (1850) |
|
| Secretary of the Interior |
Alexander H. H. Stuart (1850–1853) |
| Secretary of the Interior |
Thomas M. T. McKennan (1850) |
| Attorney General |
John J. Crittenden (1850–1853) |
| Attorney General |
Reverdy Johnson (1850) |
| Postmaster General |
Samuel D. Hubbard (1852–1853) |
| Postmaster General |
Nathan K. Hall (1850–1852) |
| Postmaster General |
Jacob Collamer (1850) |
| Secretary of the Treasury |
Thomas Corwin (1850–1853) |
| Secretary of the Treasury |
William M. Meredith (1850) |
| Secretary of the Treasury |
Thomas Ewing (1850) |
| Secretary of the Navy |
John P. Kennedy (1852–1853) |
| Secretary of the Navy |
William A. Graham (1850–1852) |
| Secretary of the Navy |
William B. Preston (1850) |
| Secretary of War |
Charles M. Conrad (1850–1853) |
| Secretary of War |
George W. Crawford (1850) |