Millard Fillmore - Administration
| First Lady | Abigail Fillmore |
| Vice President | none |
| Secretary of State | Edward Everett (1852–1853) |
| Secretary of State | John M. Clayton (1850–1850) |
| Secretary of State | Daniel Webster (1850–1852) |
| Secretary of the Interior | Alexander H. H. Stuart (1850–1853) |
| Secretary of the Interior | Thomas M. T. McKennan (1850–1850) |
| Attorney General | John J. Crittenden (1850–1853) |
| Attorney General | Reverdy Johnson (1850–1850) |
| Postmaster General | Samuel D. Hubbard (1852–1853) |
| Postmaster General | Nathan K. Hall (1850–1852) |
| Postmaster General | Jacob Collamer (1850–1850) |
| Secretary of the Treasury | William M. Meredith (1850–1850) |
| Secretary of the Treasury | Thomas Ewing (1850–1850) |
| Secretary of the Treasury | Thomas Corwin (1850–1853) |
| Secretary of the Navy | William A. Graham (1850–1852) |
| Secretary of the Navy | John P. Kennedy (1852–1853) |
| Secretary of the Navy | William B. Preston (1850–1850) |
| Secretary of War | Charles M. Conrad (1850–1853) |
| Secretary of War | George W. Crawford (1850–1850) |