| First Lady |
Florence Harding |
| Vice President |
Calvin Coolidge (1921–1923) |
| Secretary of State |
Charles Evans Hughes (1921–1923) |
| Secretary of the Interior |
Hubert Work (1923) |
| Secretary of the Interior |
Albert B. Fall (1921–1923) |
| Attorney General |
Harry M. Daugherty (1921–1923) |
| Postmaster General |
William H. Hays (1921–1922) |
| Postmaster General |
Hubert Work (1922–1923) |
| Postmaster General |
Harry S. New (1923) |
| Secretary of the Treasury |
Andrew W. Mellon (1921–1923) |
| Secretary of Labor |
James J. Davis (1921–1923) |
| Secretary of Commerce |
Herbert C. Hoover (1921–1923) |
| Secretary of Agriculture |
Henry C. Wallace (1921–1923) |
| Secretary of the Navy |
Edwin Denby (1921–1923) |
| Secretary of War |
John W. Weeks (1921–1923) |