First Lady

Florence Harding

Vice President

Calvin Coolidge (1921–1923)

Secretary of State

Charles Evans Hughes (1921–1923)

Secretary of the Interior

Hubert Work (1923)

Secretary of the Interior

Albert B. Fall (1921–1923)

Attorney General

Harry M. Daugherty (1921–1923)

Postmaster General

William H. Hays (1921–1922)

Postmaster General

Hubert Work (1922–1923)

Postmaster General

Harry S. New (1923)

Secretary of the Treasury

Andrew W. Mellon (1921–1923)

Secretary of Labor

James J. Davis (1921–1923)

Secretary of Commerce

Herbert C. Hoover (1921–1923)

Secretary of Agriculture

Henry C. Wallace (1921–1923)

Secretary of the Navy

Edwin Denby (1921–1923)

Secretary of War

John W. Weeks (1921–1923)