Franklin Pierce - Administration
| First Lady | Jane Pierce |
| Vice President | William R. D. King (1853) |
| Secretary of State | William L. Marcy (1853–1857) |
| Secretary of the Interior | Robert McClelland (1853–1857) |
| Attorney General | Caleb Cushing (1853–1857) |
| Postmaster General | James Campbell (1853–1857) |
| Secretary of the Treasury | James Guthrie (1853–1857) |
| Secretary of the Navy | James C. Dobbin (1853–1857) |
| Secretary of War | Jefferson Davis (1853–1857) |