William Harrison - Administration
| First Lady | Anna Harrison |
| Vice President | John Tyler (1841) |
| Secretary of State | Daniel Webster (1841) |
| Attorney General | John J. Crittenden (1841) |
| Postmaster General | Francis Granger (1841) |
| Secretary of the Treasury | Thomas Ewing (1841) |
| Secretary of the Navy | George E. Badger (1841) |
| Secretary of War | John Bell (1841) |