Zachary Taylor - Administration
| First Lady | Margaret Taylor |
| Vice President | Millard Fillmore (1849–1850) |
| Secretary of State | John M. Clayton (1849–1850) |
| Secretary of the Interior | Thomas Ewing (1849–1850) |
| Attorney General | Reverdy Johnson (1849–1850) |
| Postmaster General | Jacob Collamer (1849–1850) |
| Secretary of the Treasury | William M. Meredith (1849–1850) |
| Secretary of the Navy | William B. Preston (1849–1850) |
| Secretary of War | George W. Crawford (1849–1850) |